Nano Active AA is a novel azelex nanoliposome preparation (NanoLiposomal AA).
Product Name: Nano Liposomal Azelaic; Nanoactive Azelaic acid; BioaActive Azelaic acid; Soluble Azelaic acid CAS: 123-99-9

Description：

Azelex, also known as azelaic acid, is a natural saturated dicarboxylic acid containing nine carbon atoms and is an important medium-long chain dibasic acid. Featured with the effect of inhibiting excessive secretion of grease, eliminating acne and skin whitening, as well as high security, Azelex has a long history of application in cosmetics. There is no restriction on its use in the 2007 edition of Cosmetic Hygiene Code. However, due to its low solubility, high melting point (105-106 °C), vulnerability to discoloration, poor compatibility, and strong irritation, its application is greatly limited. The NanoActive AA, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and irritation, so that it is stably encapsulated in nano-carriers, and can effectively penetrate into hair follicles and the deep layer of skin, thus greatly improving absorption efficiency and bioavailability (its derivatives need to be hydrolyzed to take effect) with higher efficiency and no irritation. It is a good solution to the deficiency of azelaic acid while maintaining the original advantages. It has good compatibility and is very effective in regulating the normal secretion of sebum, eliminating acne and skin whitening.

Rhododendron and azelaic acid

Azelaic acid is a characteristic raw material:

• It can be used for freckle and acne elimination as well as oil control

• It is also used in cosmetics and pharmaceuticals
• It is featured with both excellent functionality (as a raw material for freckle and acne elimination included in the authoritative dermatological pharmacopoeia) and also has good safety.
• Although it may not show an obvious whitening effect for ordinary skin, the effect on severe pigmentation such as freckles, chloasma and melanoderma is quite noticeable.
• There have been a large number of convincing data in clinical medicine
• Unlike common functional materials, it is very stable (no unsaturated double bonds in the molecular structure)

Active mechanism of azelaic acid:

• It competitively inhibits the action of tyrosinase and blocks melanin synthesis
• It inhibits the synthesis of microbial proteins and has a strong antibacterial effect on propionibacterium acnes, staphylococcus, proteus and escherichia coli.
• Azelaic acid competitively inhibits the action of 5-α reductase, thereby inhibiting the conversion of androgen to 5-androgen aldehyde
• It inhibits the secretion of free fatty acids in sebaceous glands and regulates the normal secretion of sebum
• It removes free radicals, controls inflammation, slows down the growth of keratinocytes

Product efficacy:

• Eliminating stains and whitening skin: It has a definite and significant effect on abnormal melanin (pigmentation caused by functional disorders), such as pigmentation (marks) and malignant melanoma caused by melasma, freckles, melanoderma, trauma (or hemorrhoids, etc.).
• Curing acne, eliminating skin acne, and regulating normal secretion of sebum
• Compatible with vitamin B6, and applicable to male hormone alopecia treatment by stimulating hair growth

Product Features ：

• NanoActive AA uses FDA GRAS materials for high safety
• NanoActive SA is stable to heat, pH and shearing, so it is convenient to use.
• NanoActive AA overcomes the original shortcomings of azelaic acid while maintaining the advantages, and improves bioavailability
• NanoActive AA improves the stability of other actives in the product and facilitates absorption

Product use: it allows a wide range of applications, and can be used in various systems such as freshener, essence, cream, lotions, etc.Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%.

Product storage: keep it away from light at a temperature below 25℃.

NanoActive ISO is a novel soy isoflavone nanoliposome preparation (NanoLiposomal ISO).
Product Name: Nano Liposomal Soy Isoflaves; Nanoactive Soy Isoflavones; BioaActive Soy Isoflavones; Soluble Soy Isoflavones

CAS: 574-12-9

Description: Isoflavone is one of the flavonoids. It can be found mainly in legumes and is a secondary metabolite formed during the growth of soybeans. With a structure similar to estrogen, it is also called phytoestrogen, which can make up for the estrogen deficiency of women after 30 years old, increase skin moisture and elasticity, relieve menopausal syndrome and improve osteoporosis, thus enabling women to regain youthful charm. Soy isoflavone have been proved to be effective in anti-aging, and have a hormonal effect without side effects. However, due to the water-insolubility of soy isoflavone, it is difficult to be applied in cosmetics. NanoActive ISO is a new generation of nanoscale carrier containing soy isoflavone, which converts soy isoflavone into a completely water soluble form. By improving solubility, NanoActive ISO can easily penetrates into your skin and exerts the full effects of soy isoflavone.

Soy Isoflavone and Estradiol Structure

Soy isoflavone is featured with a similar activity to estrogen, and its main benefits to the skin include:

• Eliminating oxygen free radicals and resist aging:Promote the metabolism of skin cells and maintain skin elasticity. Prevent mature skin from degenerating due to lack of hormones
• Whitening:Inhibit tyrosinase as well as diminish chloasma and melasma
• Removing wrinkle:Promote collagen synthesis
• Skin Firming and Bust Beauty:Phytoestrogens supplement the body’s estrogen
• Inhibition to Androgen: Reduce the secretion of grease (acne skin), inhibit hair growth in arms and legs (depilatory), and promote scalp hair growth (thin hair)

NanoActive ISO encapsulates soy isoflavone in a nanoscale carrier composed of a polar lipid layer and a lipophilic core.

NanoActive is water-soluble even when it contains such an oil-soluble active as soy isoflavone. The solution is completely clear and transparent so NanoActive ISO is applicable to clear hydrogel formulations.

Formulation Advantages:

• Shearing stability
• pH stability
• Heat stability
• Improvement on skin texture
• Low viscosity

NanoActive technology improves the permeability of soy isoflavone by converting it to a water-soluble form, thereby enhancing the efficacy.

Cell Regulation of Collagen Formation and Degradation (estrogen-promoted synthesis)

The degradation signal is marked in red and the formation one in green.

E, estrogen; ER, estrogen receptor; EGFR, epidermal growth factor receptor;

TK, tyrosine kinase

                                    Nano soy isoflavone increases skin thickness

                                           Increase skin moisture

                                                      Improve skin firmness

Application

Anti-wrinkle and anti-aging cream, whitening, eliminating freckles and wrinkles, nourishing hair, facilitating hair growth, and depilatory cream

Formulation guidelines

Recommended dosage: 1% – 3%

Solubility: water and oil

pH: 2-6

Heat stability: stable

Electrolyte stability: no identified incompatibility

Shelf life: 1 year

Storage: Store with its original packaging at room temperature (<25 ° C).