NanoActive Curcumin

Posted on 02/19/201902/21/2019 by L, Y

Nanoactive Curcumin is a new type of curcumin nanoliposome (NanoLiposomal Curcumin).

Product Name: Nano Liposomal THC; Nanoactive THC; BioaActive THC; BioActive curcuminoids; NanoActive curcuminoids; Water Soluble curcuminoids; Fat Soluble curcuminoids CAS: 36062-04-1

Description: Curcumin is a yellow pigment extracted from the rhizome of Curcuma longa of the ginger family. It is an acidic polyphenolic substance with an unsaturated aliphatic and aromatic group in the main chain. According to records, the people of the Indian subcontinent have a turmeric-eating history of 5,000 years. Curcumin is now a natural product of great importance to global scientific community. In the past two decades, about 4,500 papers on curcumin have been published in various scientific journals around the world. Studies have shown that curcumin has a variety of biological activities, such as anti-oxidation, anti-infection, anti-inflammatory, anti-coagulation, anti-atherosclerosis and inhibition of tumor growth. The application of curcumin in skincare products has been widely recognised at home and abroad, and has been increasingly applied to whitening, anti-allergy,anti-inflammatory and other products. However, curcumin is difficult to dissolve in water, and easily oxidized,which limit its application in cosmetics. Nano-active materials with a particle size of less than 30 nm developed by nano-transmission system (NDS) are used to stably encapsulate curcumin in nano-carriers so that the absorption efficiency and bio-availability can be greatly increased. This has largely overcome its defects while retained its advantages, making it application is more easily and widely applicable.

Turmeric and curcumin

Curcumin has served as a traditional medicine in Asian countries for thousands of years.

The number of research papers on curcumin in recent years

Papers on curcumin nano preparation in recent years

odern biomedical research shows that curcumin has a high therapeutic effect on many diseases

Curcumin inhibits inflammatory reaction through multiple pathways

Nano-curcumin is a model for the combination of traditional medicine, modern medicine and nanotechnology

Curcumin in skincare products:

Inhibits the expression of matrix metalloproteinase 2, prevents the formation of wrinkles and melanin, increases skin thickness and elasticity by increasing the diameter and length of skin vessel
Absorbs UV rays, inhibits melanin synthesis, reduces pigmentation, and whitens the skin
Eliminate free radicals and confront skin aging
Help heal wounds and reduce scars
Cure acne and reduce acne marks
Anti-bacteria, diminish inflammation and sensitization, and provide analgesic effects
Prevent scarring and fibrosis
Prevention and treatment of skin cancer
Treatment of psoriasis

Features ：

NanoActive Nano-curcumin uses FDA GRAS grade materials for higher safety.
NanoActive Nano-curcumin is stable to heat, pH and cuts, so it is convenient to use..
NanoActive Nano-curcumin greatly improves the stability and bio-availability of nano-curcumin
NanoActive Nano-curcumin improves the stability and absorption of other actives in the product.
NanoActive Nano-curcumin is 100% water soluble and 100% oil soluble (amphiphilic)

Use:Add it at room temperature. You may heat to above 40 °C to speed up dissolution rate. Recommended dosage: 1-5%.

Storage: Keep it away from light at a temperature below 25°C.

NanoActive Vitamins (NanoActive Vitas)

Posted on 02/19/201902/21/2019 by L, Y

Anti-aging, eye bags and dark circles

NanoActive Vitas is a new multivitamin nanoliposome preparation (NanoLiposomal Vitas).
Product Name: Nanoactive Vitamin AEK; BioaActive Vitamin AEK; BioActive AEK; NanoActive AEK; Soluble Vitamin AEK;Nano Liposomal AEK

CAS: 79-81-2, 127-47-9, 10191-41-0

Dark circles and eye bags

The color of “dark circles” mainly comes from the venous blood vessels in the capillary veins of the lower eyelid. Poor partial microcirculation is one of main causes for eye swelling and eye bags, which intensifies dark circles in both optical and physiological aspects. Dark circles and bags under eyes go hand in hand, which largely undermine the appearance of the eyes. The main reasons include: fatigue ﹑fluctuating emotions, aging, weakness and lack of skincare.

Ternary multivitamin

Vitamin A can guarantee the normal state of skin tissue and maintain the normal regeneration of basal cells; Vitamin E is a highly effective antioxidant that protects cell activity; menaquinone can control blood clotting and significantly reduce the congestion of capillaries in the lower part of the eye.

Advanced Biologically Active Amphiphilic Nano- Delivery (BAAN) Technology compounds vitamins
The multiplexing of VK and VA can significantly reduce dark circles
The mixing of VE and VA can increase vitamin storage of the epidermis
The sustained release of VA is crucial for the keratinization of the epidermis
The ternary compound effects that can remove wrinkles, dark circles and reddish tone ,whiten the skin, anti-aging and sunscreen.
The product is safe, non-toxic, non-irritating and biodegradable
It does not contain any preservative system

Efficacy

Enhances metabolism and mitosis, helps maintain skin softness and elasticity, and delays skin aging
Protects cell membranes, improves skin microcirculation, and repairs skin safely and effectively
Reduces dark circles caused by fatigue and postpartum stretch marks
Anti-inflammatory, anti-wrinkle, anti-reddish and repairing, all in one

Application range

Eye care products and anti-aging products such as serum, eye mask, facial mask, skin care, etc.

Use

Add at room temperature, heating to above 40°C can speed up the dissolution rate. Recommended dosage: 1-5%. Better effects with NanoActive Q10, NanoActive Asta, etc.

Storage:Recommended to store at 2-8°C

Packing specification:1kg, 5kg, 10kg

Recommended dosage:0.5-5.0%

Experimental proof

The nano-multivitamin has little incompatibility, with a structure that can be easily combined with water molecules, showing unique advantages in the formulation.

Reduce skin roughness

18 volunteers used a cream containing 1% nano-complex vitamins twice a day

for one month. We compared them with the blank control, and used DO D15 D30 for image comparison analysis to evaluate the effect after use (see the figure below). After 30 days, the nano-multivitamin significantly smoothed and brighten the skin.

D0 D15

Complexion improvement

Twenty volunteers took clinical trials and were randomized into groups of 10 each. They were between 40 and 60 years old and of both genders. They used a facial cream containing 1% nano-complex vitamin twice a day for one month. Quantitative analyses of glossiness, clarity and complexion showed that the users’ skin appeared fresher, brighter and more vibrant (see table below).

Effect Item		Excellent	Good	Modest	Invalid
Complexion	Significant improvement	60％	20％		/
Complexion	Dull skin remission			20％	/
Brightness increase		40％	40％	20％	/
Clearness		60％	40％		/

Lighten dark circles and under-eye bags

Twenty volunteers applied a formula containing 1% nano-complex vitamins and blank products respectively to their eyelids twice a day for a month, and provided feedbacks on the differences observed after use through a self-assessment questionnaire (see table below).

Effect Item	Excellent	Good	Modest
Dark circles	Reduced by 75%	Lightened by 13%	Lessened by 12%
Bags under eyes	67% Resistable	Reduced by 33%
Crow’s feet	Reduced by 20%	Lightened by 80%

Note: 1 Good – significant improvement

NanoActive Q10（NanoActive Q10）

Posted on 02/19/201902/21/2019 by L, Y

Nanoactive Q10 is a novel white coenzyme Q10 nano-liposome preparation (NanoLiposomal Q10).
Product Name: Nano Liposomal CoQ10; Nanoactive CoQ10; BioaActive CoQ10; BioActive Coenzyme Q10; NanoActive Coenzyme Q10; Water-Soluble Coenzyme Q10; Fat-Soluble Coenzyme Q10 CAS: 303-98-0

Description: Coenzyme Q10 widely exists in mitochondria of the whole body. It has stronger antioxidant function than vitamin C and vitamin E. It can effectively eliminate free radicals and has good anti-aging, anti-wrinkle and whitening functions.” CoQ10 is a fat-soluble compound and ordinary emulsion that is difficult to be absorbed by the skin. Coenzyme Q10 Nanoactives with a particle size of less than 30 nm developed by NDS completely solves the solubility problem of CoQ10, allowing CoQ10 to be stably encapsulated in nanocarriers, which can greatly increase absorption efficiency. and bioavailability.”

Features ：

NanoActive Q10 uses FDA GRAS grade materials for high safety
NanoActive Q10 has good heat, pH and sheer stablity and is easy to use
NanoActive Q10 greatly improves the stability and bioavailability of CoQ10
NanoActive Q10 can improve the stability of other active matters in the product and facilitate absorption
NanoActive Q10 is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.

NanoActive Q10 Diluent vs. On-market Product Diluent

Efficacy:

NanoActive Q10 can increase the antioxidant effect of skin cells and reduce the damage from free radicals to the skin;
NanoActive Q10 is an active ingredient that works well to repair wrinkles, whiten and moisture skins, anti-aging, and increase skin elasticity, etc.

Use: Add it at ordinary temperature. Heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Better effect with products containing lipoic acid.

Storage: Keep it away from light at a temperature below 25℃.

CoQ10’s serial effect on the skin

CoQ10 promotes secretion of collagen I from fibroblast

Before use, after use

CoQ10’s improvement on skin texture

NanoActive AA

Posted on 02/19/201902/21/2019 by L, Y

Nano Active AA is a novel azelex nanoliposome preparation (NanoLiposomal AA).
Product Name: Nano Liposomal Azelaic; Nanoactive Azelaic acid; BioaActive Azelaic acid; Soluble Azelaic acid CAS: 123-99-9

Description：

Azelex, also known as azelaic acid, is a natural saturated dicarboxylic acid containing nine carbon atoms and is an important medium-long chain dibasic acid. Featured with the effect of inhibiting excessive secretion of grease, eliminating acne and skin whitening, as well as high security, Azelex has a long history of application in cosmetics. There is no restriction on its use in the 2007 edition of Cosmetic Hygiene Code. However, due to its low solubility, high melting point (105-106 °C), vulnerability to discoloration, poor compatibility, and strong irritation, its application is greatly limited. The NanoActive AA, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and irritation, so that it is stably encapsulated in nano-carriers, and can effectively penetrate into hair follicles and the deep layer of skin, thus greatly improving absorption efficiency and bioavailability (its derivatives need to be hydrolyzed to take effect) with higher efficiency and no irritation. It is a good solution to the deficiency of azelaic acid while maintaining the original advantages. It has good compatibility and is very effective in regulating the normal secretion of sebum, eliminating acne and skin whitening.

Rhododendron and azelaic acid

Azelaic acid is a characteristic raw material:

It can be used for freckle and acne elimination as well as oil control

It is also used in cosmetics and pharmaceuticals
It is featured with both excellent functionality (as a raw material for freckle and acne elimination included in the authoritative dermatological pharmacopoeia) and also has good safety.
Although it may not show an obvious whitening effect for ordinary skin, the effect on severe pigmentation such as freckles, chloasma and melanoderma is quite noticeable.
There have been a large number of convincing data in clinical medicine
Unlike common functional materials, it is very stable (no unsaturated double bonds in the molecular structure)

Active mechanism of azelaic acid:

It competitively inhibits the action of tyrosinase and blocks melanin synthesis
It inhibits the synthesis of microbial proteins and has a strong antibacterial effect on propionibacterium acnes, staphylococcus, proteus and escherichia coli.
Azelaic acid competitively inhibits the action of 5-α reductase, thereby inhibiting the conversion of androgen to 5-androgen aldehyde
It inhibits the secretion of free fatty acids in sebaceous glands and regulates the normal secretion of sebum
It removes free radicals, controls inflammation, slows down the growth of keratinocytes

Product efficacy:

Eliminating stains and whitening skin: It has a definite and significant effect on abnormal melanin (pigmentation caused by functional disorders), such as pigmentation (marks) and malignant melanoma caused by melasma, freckles, melanoderma, trauma (or hemorrhoids, etc.).
Curing acne, eliminating skin acne, and regulating normal secretion of sebum
Compatible with vitamin B6, and applicable to male hormone alopecia treatment by stimulating hair growth

Product Features ：

NanoActive AA uses FDA GRAS materials for high safety
NanoActive SA is stable to heat, pH and shearing, so it is convenient to use.
NanoActive AA overcomes the original shortcomings of azelaic acid while maintaining the advantages, and improves bioavailability
NanoActive AA improves the stability of other actives in the product and facilitates absorption

Product use: it allows a wide range of applications, and can be used in various systems such as freshener, essence, cream, lotions, etc.Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%.

Product storage: keep it away from light at a temperature below 25℃.

NanoActive ISO

Posted on 02/19/201902/21/2019 by L, Y

NanoActive ISO is a novel soy isoflavone nanoliposome preparation (NanoLiposomal ISO).
Product Name: Nano Liposomal Soy Isoflaves; Nanoactive Soy Isoflavones; BioaActive Soy Isoflavones; Soluble Soy Isoflavones

CAS: 574-12-9

Description: Isoflavone is one of the flavonoids. It can be found mainly in legumes and is a secondary metabolite formed during the growth of soybeans. With a structure similar to estrogen, it is also called phytoestrogen, which can make up for the estrogen deficiency of women after 30 years old, increase skin moisture and elasticity, relieve menopausal syndrome and improve osteoporosis, thus enabling women to regain youthful charm. Soy isoflavone have been proved to be effective in anti-aging, and have a hormonal effect without side effects. However, due to the water-insolubility of soy isoflavone, it is difficult to be applied in cosmetics. NanoActive ISO is a new generation of nanoscale carrier containing soy isoflavone, which converts soy isoflavone into a completely water soluble form. By improving solubility, NanoActive ISO can easily penetrates into your skin and exerts the full effects of soy isoflavone.

Soy Isoflavone and Estradiol Structure

Soy isoflavone is featured with a similar activity to estrogen, and its main benefits to the skin include:

Eliminating oxygen free radicals and resist aging:Promote the metabolism of skin cells and maintain skin elasticity. Prevent mature skin from degenerating due to lack of hormones
Whitening:Inhibit tyrosinase as well as diminish chloasma and melasma
Removing wrinkle:Promote collagen synthesis
Skin Firming and Bust Beauty:Phytoestrogens supplement the body’s estrogen
Inhibition to Androgen: Reduce the secretion of grease (acne skin), inhibit hair growth in arms and legs (depilatory), and promote scalp hair growth (thin hair)

NanoActive ISO encapsulates soy isoflavone in a nanoscale carrier composed of a polar lipid layer and a lipophilic core.

NanoActive is water-soluble even when it contains such an oil-soluble active as soy isoflavone. The solution is completely clear and transparent so NanoActive ISO is applicable to clear hydrogel formulations.

Formulation Advantages:

Shearing stability
pH stability
Heat stability
Improvement on skin texture
Low viscosity

NanoActive technology improves the permeability of soy isoflavone by converting it to a water-soluble form, thereby enhancing the efficacy.

Cell Regulation of Collagen Formation and Degradation (estrogen-promoted synthesis)

The degradation signal is marked in red and the formation one in green.

E, estrogen; ER, estrogen receptor; EGFR, epidermal growth factor receptor;

TK, tyrosine kinase

Nano soy isoflavone increases skin thickness

Increase skin moisture

Improve skin firmness

Application

Anti-wrinkle and anti-aging cream, whitening, eliminating freckles and wrinkles, nourishing hair, facilitating hair growth, and depilatory cream

Formulation guidelines

Recommended dosage: 1% – 3%

Solubility: water and oil

pH: 2-6

Heat stability: stable

Electrolyte stability: no identified incompatibility

Shelf life: 1 year

Storage: Store with its original packaging at room temperature (<25 ° C).

Nano phenethyl resorcinol (NanoActive 377)

Posted on 02/19/201902/21/2019 by L, Y

Nano phenylethyl resorcinol (NanoActive 377) is a new type of phenethyl resorcinol nanoliposome preparation (NanoLiposomal 377).
Product Name: Nano Liposomal 377; BioActive Phenylethyl Resorcinol; NanoActive 377; NanoAcive Phenylethyl Resorcinol; Water-Soluble 377; Fat-Soluble 377 CAS: 85-27-8

Description: Phenylethyl resorcinol is a new high-efficiency skin whitening agent derived from silver pine, which has ultra-strong potential whitening effect: In Vitro Experiments have also proved that it is ten or even hundred times stronger than that of VC. And it has also been clinically proven to its whitening ability is equivalent to that of hydroquinone. The most important thing among it is that the whitening speed is fast and is favoring to consumers. After more than ten years of continuous studying of the nature and safety of these raw materials, this emerging high-efficiency natural active substance is gradually getting permission from various countries and gradually used in cosmetics. Phenylethyl resorcinol is poorly soluble in water and susceptible to oxidization and discoloration, which limits its application in cosmetics. Nano actives with a particle size of less than 30 nm developed by nano-transmission system (NDS) enable phenylethyl resorcinol to be steadily wrapped in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects and retains the advantages with a more convenient and wider range of uses.

Phenylethyl resorcinol

Skin care effects

Phenylethyl resorcinol can effectively inhibit melanin synthesis by acting on multiple targets of the melanin synthesis pathway, thereby achieving whitening and brightening effect. Super antioxidant, effectively removes harmful free radicals from the skin, prevents wrinkles caused by aging and free radicals.

SymWhite 377 effectively inhibits the activity of B16 melanoma to form melanin, which is 210 times the kojia acid, and 32 times the arbutin!

Tyrosinase inhibitory activity

Whitening test–skin model

Clinical trial (unirradiated skin)

Features

Added NanoActive 377 to the formula and the color remained the same.
NanoActive 377 uses FDA GRAS grade materials for high safety
NanoActive E has good heat, pH and shear stability and is easy to use
NanoActive 377 greatly improves the stability and bioavailability
NanoActive 377 can improve the stability of other active matters in the product and facilitate absorption
NanoActive E is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of application.

Applications

Inhibits melanin synthesis, reduces pigmentation and whitens the skin
Eliminate free radicals and prevent skin aging.
Reduce acne marks

The market claims:

Originated from the essence of evergreen conifer
Is a powerful whitening ingredient
Effectively evens skin tone, leaving skin quickly regaining whiteness, clearness, and regaining the bright skin tone of young skin.
Lightens dark spots, and the skin becomes bright after use
A powerful antioxidant that can be used to fight harmful free radicals that cause skin aging
Mild texture, no side effects that irritate the skin
Ultra-micro-nano wrapping technology, effective penetration and does not change color

Use: add it at room temperature. Heat it to above 40℃to speed up the dissolution. Recommended dosage: 0.1-5%. The optimum pH range of the system is 3.0-6.5, and the finished product should be protected from direct sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

Storage: Keep it away from light at a temperature below 25℃.

NanoActive RES

Posted on 02/19/201902/21/2019 by L, Y

Nanoactive Res is a novel resveratrol nanoliposome preparation (NanoLiposomal Resveratrol).
Product Name: Nano Liposomal Res, Nanoactive Res; BioActive Resveratrol; NanoActive Resveratrol CAS: 501-36-0

Description: Resveratrol (“Res”) is a non-flavonoid polyphenolic compound. A Japanese called Tokaoka was the first one who obtained it by separating it from the roots of Veratrum granginorumin 1940. With the in-depth study of resveratrol, it has been shown that resveratrol has a wide range of activities such as anti-cancer, anti-oxidation, anti-bacteria and anti-inflammation which can be broadly used in medicine, health care products, food, cosmetics and other fields. Resveratrol has many targets in the skin, so it can be used as a skincare product to produce whitening, anti-wrinkle, anti-bacteria, anti-inflammation, acne curing and anti-aging effects. It is an emerging natural active substance with high efficiency. However, resveratrol is hardly soluble in water while easy to be oxidized and discolored, which limits its application in cosmetics. The nano actives, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, and enables the resveratrol to be steadily encapsulated in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects while maintaining the advantages with a more convenient and wider range of uses.

Resveratrol

Number of papers on resveratrol in PUBMED over years

Resveratrol can effectively prolong life span

Skincare effect

Resveratrol is a natural antioxidant present in plants. Its antioxidant capacity is 20-50 times that of L-C. If applied simultaneously with L-C, the effect will be multiplied. Resveratrol inhibits collagenase, reduces collagen degradation, promotes collagen proliferation, and firms skin. Resveratrol allows cells to enhance their self-defense enzymes, thereby repairing damaged DNA, while effectively inhibiting oncogenic proteins produced by UVB exposure. Resveratrol can effectively inhibit melanin synthesis by reacting with multiple targets required for melanin synthesis, thereby achieving whitening and brightening effect.

Resveratrol inhibits melanin synthesis through multiple targets

Features

NanoActive RES uses FDA GRAS grade materials for high safety
NanoActive RES is stable to heat, pH and shearing, so it is convenient to use.
NanoActive RES greatly improves the stability and bioavailability of resveratrol
NanoActive RES can improve the stability of other active matters in the product and facilitate absorption
NanoActive RES is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.

Applications

Promote collagen synthesis, improve skin thickness and elasticity, remove wrinkles, and firm your skin
Inhibit melanin synthesis, reduce pigmentation and whiten your skin
Eliminate free radicals and confront skin aging
Promote wound healing and reduce scars
Cure acne and reduce acne marks.
Anti-bacteria, diminish inflammation and sensitization, and provide analgesic effects
Prevent scarring and fibrosis

Use:Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. The optimum pH range of the system is 3.0-6.5, and the finished product should be protected from direct exposure to sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

Storage: Keep it away from light at a temperature below 25℃.

Experimental proof