Good anti-irritant ingredients Effectively reduces itching and erythema Antihistamine, anti-oxidation Reduces inflammation symptoms.
Description
INCI name:HYDROXYPHENYL PROPAMIDOBENZOIC ACID, PROPYLENE GLYCOL, BUTYLENE GLYCOL, PHOSPHOLIPIDS, TOCOPHERYL ACETATE, Dihydroavenanthramide D
CAS: 697235-49-7.
Traits: colorless to yellow liquid
Recommended amount: 0.1-5%
It is a kind of water-soluble liposome encapsulated active ingredients, and can be miscible with water in any proportion, so it is convenient and highly active. Clinical evidence shows that oat alkaloids are a powerful non-steroidal anti-inflammatory and antipruritic natural ingredient with a potency comparable to hydrocortisone, but without any side effects of steroid hormones. NanoCalmin have anti-inflammatory, anti-allergic, anti-irritant, rapid antipruritic, antihistamine, immune regulation, antifibrotic (anti-scarring), and anti-erythema effects. It can also effectively relieve itching, irritation, and redness of sensitive skin. PuriPharm can provide NanoCalmin powder with a high concentration of 99%.
Overview
Hydroxyphenyl Propamidobenzoic acid is derived from the active ingredient of oat (Avena Sativa), also known as dihydro oat acyl anthranilic acid, oat Avenanthramides or oat amide.
Oat amide is an antioxidant substance unique in oat and has the highest content in the aleurone layer.
Oat amide is used in bath product additives to relieve dry skin symptoms and skin itching.
About Allergic Reactions
Allergy is the overreaction of the immune system to certain foreign substances that brought into contact with the body.
Allergic reactions can occur at any age.
The most important factor affecting allergic reactions is heredity. Another major influencing factor is the environment.
Inferior skin care products can also cause skin allergic reaction.
NanoCalmin’s Efficacy
Hydroxyphenyl Propamidobenzoic acid and Tranilast are similar in structure .Tranilast has very powerful effects: anti-inflammatory, anti-allergic, anti-irritation, fast anti-itch, antihistamine, immunomodulation, anti-fibrosis (anti-scarring), anti-erythema.
The difference between Hydroxyphenyl Propamidobenzoic acid and anti-allergic drugs is that Hydroxyphenyl Propamidobenzoic acid inhibits allergic reaction as a therapeutic treatment, which can effectively prevent the occurrence and development of allergic reactions .
Hydroxyphenyl Propamidobenzoic acid has less side effects than antihistamines and glucocorticoids, and has a significant therapeutic effect on anti-allergy .
Test to verify the effect of Hydroxyphenyl Propamidobenzoic acid against skin itching and blister erythema caused by histamine .
Test parameters:
Itching: the number of times of tickling Skin.
erythema: relative initial erythema area .
Histamine hydrochloride (10mg/ml) was added to the skin test site by a specific method.
Application of histamine can cause severe itching, erythema, blisters.
Hydroxyphenyl Propamidobenzoic acid can significantly alleviate skin abnormalities caused by histamine, such as itching, redness and blisters.
Hydroxyphenyl Propamidobenzoic acid has a dose-dependent effect on skin itching and erythema relief.
Hydroxyphenyl Propamidobenzoic acid has a mitigating effect on histamine-induced skin itching and erythema at very low concentrations.
NanoCalmin’s Safety
Some experts have studied the functional role of Hydroxyphenyl Propamidobenzoic acid in animals.
The mice were fed in 2 groups. One is normal and the other added Hydroxyphenyl Propamidobenzoic acid at a dose of 0.1 g/kg, the purpose of which is to see the ability of this substance to regulate the tissue oxidation and antioxidant balance in the mice.
In addition, 50 days after feeding the mice, the two groups of mice were divided into the exercise group and the non-exercise group to study the effect of Hydroxyphenyl Propamidobenzoic acid on the oxidation induced by exercise in the internal organs of mice.
The results showed that supplementation of Hydroxyphenyl Propamidobenzoic acid had no effect on the production of reactive oxygen species in most tissues except for the reduction of reactive oxygen species in the soleus muscle of mice, indicating that Hydroxyphenyl Propamidobenzoic acid does not affect cellular energy metabolism.
Supplementation with Hydroxyphenyl Propamidobenzoic acid improves superoxide dismutase activity in the thigh muscles, liver, and kidney, and increases glutathione peroxidase activity in the thigh muscles and heart. Exercise can increase reactive oxygen species in muscle and myocardium to accelerate the peroxidation of heart, liver and muscle. It has been found through experiments that oat amide can slow down the production of reactive oxygen species caused by muscle movement and reduce the phenomenon of fat peroxidation in the heart.
This indicates that oat amide should be added as an effective antioxidant to the diet.
NanoCalmin’s Application
Hydroxyphenyl Propamidobenzoic acid has good efficacy but poor water solubility .
NanoCalmin is nano-coated so as to give Hydroxyphenyl Propamidobenzoic acid better stability, efficacy and safety, and at the same time is easy to use in formula .
NanoCalmin contains 5% Hydroxyphenyl Propamidobenzoic acid .
NanoCalmin utilizes a nano-delivery system (NDS) that not only solves the solubility problems and stability problems of biopolyphenols and dihydro oatAvenanthramides, but also greatly increases absorption efficiency and bioavailability.
20% NanoCalmin aqueous solution
NanoCalmin is lighter in color than the commercially available solution containing 5% Hydroxyphenyl Propamidobenzoic acid.
NanoCalmin is very soluble in water and does not affect the pH of the system .
Formulation Guidelines
Suggested addition amount: 0.1-5%
How to use: Add at 45 ° C (stable to heat)
Solubility: good water solubility
Use pH: 3-8
Attention: it should be preserved at low-temperature and dark place.
Compatibility: No incompatibility found at present.
Conclusion
Efficient ingredients in anti-irritant and inflammation reduction.
Effectively reduces itching and redness .
Antihistamine, anti-oxidation.
Easy to formulate.
Wide range of applications.
Hhave a remarkable effect on skin care, hair care, body care and scalp care.