NanoActive AA

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Nano Active AA is a novel azelex nanoliposome preparation (NanoLiposomal AA).
Product Name: Nano Liposomal Azelaic; Nanoactive Azelaic acid; BioaActive Azelaic acid; Soluble Azelaic acid CAS: 123-99-9

Description：

Azelex, also known as azelaic acid, is a natural saturated dicarboxylic acid containing nine carbon atoms and is an important medium-long chain dibasic acid. Featured with the effect of inhibiting excessive secretion of grease, eliminating acne and skin whitening, as well as high security, Azelex has a long history of application in cosmetics. There is no restriction on its use in the 2007 edition of Cosmetic Hygiene Code. However, due to its low solubility, high melting point (105-106 °C), vulnerability to discoloration, poor compatibility, and strong irritation, its application is greatly limited. The NanoActive AA, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and irritation, so that it is stably encapsulated in nano-carriers, and can effectively penetrate into hair follicles and the deep layer of skin, thus greatly improving absorption efficiency and bioavailability (its derivatives need to be hydrolyzed to take effect) with higher efficiency and no irritation. It is a good solution to the deficiency of azelaic acid while maintaining the original advantages. It has good compatibility and is very effective in regulating the normal secretion of sebum, eliminating acne and skin whitening.

Rhododendron and azelaic acid

Azelaic acid is a characteristic raw material:

 

 

 

 

 

 

 

 

  • It can be used for freckle and acne elimination as well as oil control

 

  • It is also used in cosmetics and pharmaceuticals
  • It is featured with both excellent functionality (as a raw material for freckle and acne elimination included in the authoritative dermatological pharmacopoeia) and also has good safety.
  • Although it may not show an obvious whitening effect for ordinary skin, the effect on severe pigmentation such as freckles, chloasma and melanoderma is quite noticeable.
  • There have been a large number of convincing data in clinical medicine
  • Unlike common functional materials, it is very stable (no unsaturated double bonds in the molecular structure)

 

Active mechanism of azelaic acid:

  • It competitively inhibits the action of tyrosinase and blocks melanin synthesis
  • It inhibits the synthesis of microbial proteins and has a strong antibacterial effect on propionibacterium acnes, staphylococcus, proteus and escherichia coli.
  • Azelaic acid competitively inhibits the action of 5-α reductase, thereby inhibiting the conversion of androgen to 5-androgen aldehyde
  • It inhibits the secretion of free fatty acids in sebaceous glands and regulates the normal secretion of sebum
  • It removes free radicals, controls inflammation, slows down the growth of keratinocytes

 

Product efficacy:

  • Eliminating stains and whitening skin: It has a definite and significant effect on abnormal melanin (pigmentation caused by functional disorders), such as pigmentation (marks) and malignant melanoma caused by melasma, freckles, melanoderma, trauma (or hemorrhoids, etc.).
  • Curing acne, eliminating skin acne, and regulating normal secretion of sebum
  • Compatible with vitamin B6, and applicable to male hormone alopecia treatment by stimulating hair growth

 

Product Features ：

  • NanoActive AA uses FDA GRAS materials for high safety
  • NanoActive SA is stable to heat, pH and shearing, so it is convenient to use.
  • NanoActive AA overcomes the original shortcomings of azelaic acid while maintaining the advantages, and improves bioavailability
  • NanoActive AA improves the stability of other actives in the product and facilitates absorption

 

Product use: it allows a wide range of applications, and can be used in various systems such as freshener, essence, cream, lotions, etc.Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%.

 

Product storage: keep it away from light at a temperature below 25℃.

NanoActive ISO

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NanoActive ISO is a novel soy isoflavone nanoliposome preparation (NanoLiposomal ISO).
Product Name: Nano Liposomal Soy Isoflaves; Nanoactive Soy Isoflavones; BioaActive Soy Isoflavones; Soluble Soy Isoflavones

CAS: 574-12-9

Description: Isoflavone is one of the flavonoids. It can be found mainly in legumes and is a secondary metabolite formed during the growth of soybeans. With a structure similar to estrogen, it is also called phytoestrogen, which can make up for the estrogen deficiency of women after 30 years old, increase skin moisture and elasticity, relieve menopausal syndrome and improve osteoporosis, thus enabling women to regain youthful charm. Soy isoflavone have been proved to be effective in anti-aging, and have a hormonal effect without side effects. However, due to the water-insolubility of soy isoflavone, it is difficult to be applied in cosmetics. NanoActive ISO is a new generation of nanoscale carrier containing soy isoflavone, which converts soy isoflavone into a completely water soluble form. By improving solubility, NanoActive ISO can easily penetrates into your skin and exerts the full effects of soy isoflavone.

Soy Isoflavone and Estradiol Structure

Soy isoflavone is featured with a similar activity to estrogen, and its main benefits to the skin include:

  • Eliminating oxygen free radicals and resist aging:Promote the metabolism of skin cells and maintain skin elasticity. Prevent mature skin from degenerating due to lack of hormones
  • Whitening:Inhibit tyrosinase as well as diminish chloasma and melasma
  • Removing wrinkle:Promote collagen synthesis
  • Skin Firming and Bust Beauty:Phytoestrogens supplement the body’s estrogen
  • Inhibition to Androgen: Reduce the secretion of grease (acne skin), inhibit hair growth in arms and legs (depilatory), and promote scalp hair growth (thin hair)

NanoActive ISO encapsulates soy isoflavone in a nanoscale carrier composed of a polar lipid layer and a lipophilic core.

NanoActive is water-soluble even when it contains such an oil-soluble active as soy isoflavone. The solution is completely clear and transparent so NanoActive ISO is applicable to clear hydrogel formulations.

Formulation Advantages:

  • Shearing stability
  • pH stability
  • Heat stability
  • Improvement on skin texture
  • Low viscosity

NanoActive technology improves the permeability of soy isoflavone by converting it to a water-soluble form, thereby enhancing the efficacy.

Cell Regulation of Collagen Formation and Degradation (estrogen-promoted synthesis)

The degradation signal is marked in red and the formation one in green.

E, estrogen; ER, estrogen receptor; EGFR, epidermal growth factor receptor;

TK, tyrosine kinase

                                    Nano soy isoflavone increases skin thickness

                                           Increase skin moisture

                                                      Improve skin firmness

 

 

Application

Anti-wrinkle and anti-aging cream, whitening, eliminating freckles and wrinkles, nourishing hair, facilitating hair growth, and depilatory cream

Formulation guidelines

Recommended dosage: 1% – 3%

Solubility: water and oil

pH: 2-6

Heat stability: stable

Electrolyte stability: no identified incompatibility

Shelf life: 1 year

Storage: Store with its original packaging at room temperature (<25 ° C).

Nano phenethyl resorcinol (NanoActive 377)

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Nano phenylethyl resorcinol (NanoActive 377) is a new type of phenethyl resorcinol nanoliposome preparation (NanoLiposomal 377).
Product Name: Nano Liposomal 377; BioActive Phenylethyl Resorcinol; NanoActive 377; NanoAcive Phenylethyl Resorcinol; Water-Soluble 377; Fat-Soluble 377 CAS: 85-27-8

Description: Phenylethyl resorcinol is a new high-efficiency skin whitening agent derived from silver pine, which has ultra-strong potential whitening effect: In Vitro Experiments have also proved that it is ten or even hundred times stronger than that of  VC. And it has also been clinically proven to its whitening ability is equivalent to that of hydroquinone. The most important thing among it is that the whitening speed is fast and is favoring to consumers. After more than ten years of continuous studying of the nature and safety of these raw materials, this emerging high-efficiency natural active substance is gradually getting permission from various countries and gradually used in cosmetics. Phenylethyl resorcinol is poorly soluble in water and susceptible to oxidization and discoloration, which limits its application in cosmetics. Nano actives with a particle size of less than 30 nm developed by nano-transmission system (NDS) enable phenylethyl resorcinol to be steadily wrapped in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects and retains the advantages with a more convenient and wider range of uses.

Phenylethyl resorcinol

Skin care effects

Phenylethyl resorcinol can effectively inhibit melanin synthesis by acting on multiple targets of the melanin synthesis pathway, thereby achieving whitening and brightening effect. Super antioxidant, effectively removes harmful free radicals from the skin, prevents wrinkles caused by aging and free radicals.

SymWhite 377 effectively inhibits the activity of B16 melanoma to form melanin, which is 210 times the kojia acid, and 32 times the arbutin!

 

Tyrosinase inhibitory activity

 

Whitening test–skin model

Clinical trial (unirradiated skin)

Features

  • Added NanoActive 377 to the formula and the color remained the same.
  • NanoActive 377 uses FDA GRAS grade materials for high safety
  • NanoActive E has good heat, pH and shear stability and is easy to use
  • NanoActive 377 greatly improves the stability and bioavailability
  • NanoActive 377 can improve the stability of other active matters in the product and facilitate absorption
  • NanoActive E is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of application.

 

Applications

  • Inhibits melanin synthesis, reduces pigmentation and whitens the skin
  • Eliminate free radicals and prevent skin aging.
  • Reduce acne marks

The market claims:

  • Originated from the essence of evergreen conifer
  • Is a powerful whitening ingredient
  • Effectively evens skin tone, leaving skin quickly regaining whiteness, clearness, and regaining the bright skin tone of young skin.
  • Lightens dark spots, and the skin becomes bright after use
  • A powerful antioxidant that can be used to fight harmful free radicals that cause skin aging
  • Mild texture, no side effects that irritate the skin
  • Ultra-micro-nano wrapping technology, effective penetration and does not change color

Use: add it at room temperature. Heat it to above 40℃to speed up the dissolution. Recommended dosage: 0.1-5%. The optimum pH range of the system is 3.0-6.5, and the finished product should be protected from direct sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

Storage: Keep it away from light at a temperature below 25℃.

NanoActive RES

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Nanoactive Res is a novel resveratrol nanoliposome preparation (NanoLiposomal Resveratrol).
Product Name: Nano Liposomal Res, Nanoactive Res; BioActive Resveratrol; NanoActive Resveratrol CAS: 501-36-0

Description: Resveratrol (“Res”) is a non-flavonoid polyphenolic compound. A Japanese called Tokaoka was the first one who obtained it by separating it from the roots of Veratrum granginorumin 1940. With the in-depth study of resveratrol, it has been shown that resveratrol has a wide range of activities such as anti-cancer, anti-oxidation, anti-bacteria and anti-inflammation which can be broadly used in medicine, health care products, food, cosmetics and other fields. Resveratrol has many targets in the skin, so it can be used as a skincare product to produce whitening, anti-wrinkle, anti-bacteria, anti-inflammation, acne curing and anti-aging effects. It is an emerging natural active substance with high efficiency. However, resveratrol is hardly soluble in water while easy to be oxidized and discolored, which limits its application in cosmetics. The nano actives, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, and enables the resveratrol to be steadily encapsulated in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects while maintaining the advantages with a more convenient and wider range of uses.

 

 

 

 

 

 

   Resveratrol

                   

 

 

 

 

 

 

 

  Number of  papers on resveratrol in PUBMED over years

 

 

 

 

 

 

 

Resveratrol can effectively prolong life span

Skincare effect

Resveratrol is a natural antioxidant present in plants. Its antioxidant capacity is 20-50 times that of L-C. If applied simultaneously with L-C, the effect will be multiplied. Resveratrol inhibits collagenase, reduces collagen degradation, promotes collagen proliferation, and firms skin. Resveratrol allows cells to enhance their self-defense enzymes, thereby repairing damaged DNA, while effectively inhibiting oncogenic proteins produced by UVB exposure. Resveratrol can effectively inhibit melanin synthesis by reacting with multiple targets required for melanin synthesis, thereby achieving whitening and brightening effect.

 

 

 

 

Resveratrol inhibits melanin synthesis through multiple targets

 

Features

  • NanoActive RES uses FDA GRAS grade materials for high safety
  • NanoActive RES is stable to heat, pH and shearing, so it is convenient to use.
  • NanoActive RES greatly improves the stability and bioavailability of resveratrol
  • NanoActive RES can improve the stability of other active matters in the product and facilitate absorption
  • NanoActive RES is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.

 

Applications

  • Promote collagen synthesis, improve skin thickness and elasticity, remove wrinkles, and firm your skin
  • Inhibit melanin synthesis, reduce pigmentation and whiten your skin
  • Eliminate free radicals and confront skin aging
  • Promote wound healing and reduce scars
  • Cure acne and reduce acne marks.
  • Anti-bacteria, diminish inflammation and sensitization, and provide analgesic effects
  • Prevent scarring and fibrosis

 

Use:Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. The optimum pH range of the system is 3.0-6.5, and the finished product should be protected from direct exposure to sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

Storage: Keep it away from light at a temperature below 25℃.

Experimental proof

 

                     Resveratrol inhibits intracellular melanin synthesis

 

                      Resveratrol tyrosinase activity is superior to kojic acid

 

Low concentration of resveratrol (0.001%) can reduce B16F10 cell melanin by 50%

      Two-week application can provide noticeable whitening effect

 

                       Resveratrol has obvious anti-wrinkle effect

Resveratrol (0.001%) is effective in treating acne

Before RES treatment                                  After RES (0.001%) treatment

PIONIN

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Highly Efficient in Anti-Bacteria & Anti-Melanin
Highly efficient with very low dose of use
Borad activity to resist bacteria, fungi and pathogens.
0.00002% PIONIN can inhibit the growth of
propionibacterium acnes
0.00001% PIONIN can inhibit 83 % melanin formation

Anit-acne: quickly and significantly reduce spots
Reduce 50% of spots or rashes within 2 weeks

Preservative activity: improve the efficacy of
parabens or completely replace them

High security
Compliant with Japanese Quasi Drugsto be used in anti-acne products

           ⇒            

Fast & deep effect on anti-acne & anti-freckle effect
In Vitro Test : Strongly inhibit propionibacterium acnes.


In Vivo Tests: Effectively reduce propionibacterium acnes.


Number of propionibacterium acnes on the skin during skin care process.
Clinical Test: Within two weeks, it reduced 50% spots
Testing program: Carry out test in 38 testees with acne problems.
Method: Wash face 3 times every day with emulsion containing 0.001% of PIONIN and smears twice a week with cream containing 0.005% of PIONIN.

Bactericidal activity : PIONIN can be used as a preservative
The PIONIN’s bactericidal ability allows it to be used as a preservative. In vitro test data shows that in term of anti-bacteria and anti-fungi of various kinds, PIONIN is more effective than paraben methyl ester. Therefore, just adding a small amount of paraben in the formulation containing PIONIN is enough to achieve an antibacterial effect.


PIONIN can be used alone ( See the picture below, the number of E. coli contained in 0.002% PIONIN ).
PIONIN can compensate for the methylparaben ( Adding 0.002% PIONIN can lead to an increase of anti-E. Coli activity of 0.05% Methylparaben).
When mixed with polyols, PIONIN can completely replace parabens as a preservative.

Highly efficient molecule in anti-bacteria & anti-melanin
PIONIN similar to cyanine dyes. Even a single PIONIN molecule also has anti-bacterial activity, which is the reason why PIONIN is still efficient even with an extremely low dose:
-resistant to propionibacterium acnes
and inhibits melanin production
-improves the corrosion resistance
of finished products


By causing collapse of cell membrane and cell wall and intracelluar degradation, PIONIN will damage the microorganisms.

Inhibits bacteria and fungi with an extremely low dose of use ( In vitro test )
In vitro test (see table below, agar plate dilution) proves that the extremely low dose of use of PIONIN can also inhibit a wide range of bacteria and fungi. The lowest concentration of PIONIN used to inhibit bacterial growth is called the Minimum Inhibitory Concentration (MIC).

Strong inhibition of melanin
PIONIN can prevent the formation of melanin. In vitro test indicates that:
– 0.000003% PIONIN can suppress 50% melanin formation
– 0.00001% PIONIN can suppress 83% melanin formation.
In contrast, 0.07% kojic acid can inhibit 100% melanin formation.

Highly safe and non-irritant
Human body patch test ( human body, 0.2%, 48 hours ): negative
Initial skin irritation ( rabbit, 0.2%, 24 hours ): negative
Sustained skin irritation ( rabbit, 0.01%, 90 day ): negative
Eye irritation ( rabbit, 0.0007%, 24 hour ): negative
Skin sensitization ( Guinea pig, 0.2%, maximum test ): negative
Phototoxicity ( rabbit, 0.2%): negative
Photosensitization ( Guinea Pig, 0.2%, Adjuvant-Strip Method ): negative
Induced gene mutation (10μg, Ames test, ±S9 mix): negative
Acute Toxicity LD 50 ( mouse )： 325 mg/kg

Application : Aniti-acne, anti-freckle, whitening, cleansing
Anti-acne, oily skin, anti-freckle
Whitening
Cleaning formula, hand cream

Definition
Commodity names : PIONIN
English name : BIOXYNE
INCI name : Quaternary Ammonium Salt -73
China INCI (2007): has been included
China INCI (2010): has been included
CAS#: 15763-48-1
EINECS#: 239-852-5
Related regulations : Compliant with Japanese Quasi-drugs for using in acne products.

Formula Guidelines

Technical indicators

Storage