NanoActive FA is a novel ferulic acid nanoliposome preparation (NanoLiposomal AA).
Product Name: Nano Liposomal Ferulic Acid; Nanoactive Ferulic Acid; BioaActive Ferulic Acid; BioActive FA; NanoActive FA; Soluble Ferulic Acid

CAS: 1135-24-6

Description: Ferulic acid is an organic acid isolated from Ferula foetida regel in 1866. Ferulic acid is an intercellular adhesive that binds the polysaccharides among cells to make the skin firm and elastic. Ferulic acid survives in the blood longer than L-C and is one of the ultimate anti-oxidant warriors. Ferulic acid is a fat-soluble antioxidant. Compared with vitamin E, ferulic acid has a better effect on removing fat-soluble free radicals. The content of ferulic acid is high in Chinese herbal medicines such as Ferula foetida regel, Angelica sinensis, Ligusticum wallichii, Cimicifuga foetida, and seeds of wild jujubes, and it is an active ingredient in these traditional Chinese medicines. It is effective in eliminating free radicals, anti-thrombus, anti-bacteria, anti-inflammation, inhibiting tumor, preventing hypertension, and heart diseases, enhancing the vitality of sperm as well as other health functions and protecting the skin.

Ferula foetida regel                                            Ferulic acid

Features

• NanoActive FA uses FDA GRAS (Generally Recognized as Safe) materials so it is highly safe.
• NanoActive FA has a good stability towards heat, pH and shearing, so it is easy to use.
• NanoActive FA greatly improves the stability and bioavailability of ferulic acid.
• NanoActive FA improves the stability and absorption of other actives in the product.
• NanoActive FA is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.

Efficacy

• Firming: Combine the polysaccharides among cells to make your skin firmer (sagging eyelids, skin slackness after weight loss and pregnancy)
• Anti-aging: Confront free radicals (fat-soluble antioxidants)
• Whitening and evening skin tone: Absorb UVB and inhibit the formation of melanin (whitening by preventing tyrosinase synthesis of melanin through competitive inhibiting method)

Use:Add this product at room temperature and heat it to above 40 °C to speed up its dissolution. Recommended dosage: 1-5%. It works better with products such as Nano Vitamin C and Nano Vitamin E.

Storage: Keep it away from light at a temperature below 25℃.

Experimental proof

Black Cell Producing Effect of Ferulic Acid

Inhibiting Effect of Ferulic Acid against Tyrosinase Activity

Effect of Ferulic Acid on Skin Tone

Effect of Ferulic Acid on Hair

NanoActive phytosterol is a new phytosterol nanoliposome preparation (NanoLiposomal phytosterol).
Product Name: Nano Liposomal Phytosterosl; Nanoactive PHYTOSTEROLS; BioaActive PHYTOSTEROLS; Soluble PHYTOSTEROLS CAS: 68441-03-2

Description: Phytosterol is a kind of substance with cyclopentane perhydrophenanthrene (also known as steroid nucleus) as its frame. It is similar in structure to animal sterols such as cholesterol, and is in free or binding state in nature. Known as the “key to life” and widely found in plants, phytosterol is a kind of natural physiologically active substances beneficial to humans. It can inhibit the cholesterol absorption of humans, promote the degradation and metabolism of cholesterol, inhibit the biosynthesis of cholesterol, etc., and has been found to have the function of inhibiting cardiovascular diseases in animal studies. Also, it is effective in anti-cancer, anti-tumor, anti-inflammatory, improving immunity, regulating growth, anti-virus, anti-oxidation, etc. In recent years, it has been proved that phytosterol has skincare effects such as anti-inflammatory, anti-irritation, moisturizing and anti-wrinkle. However, its poor solubility in water and oil, and demulsification when added in the formulation limit the application in cosmetics. The NanoActive phytosterol, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and enables phytosterol to be stably encapsulated in nano-carriers, thus greatly improving absorption efficiency and bioavailability.

Main component structure of phytosterol

Cholesterol is an important component of the epidermal layer of skin and plays an important role in maintaining skin health, but direct application of cholesterol to the skin can cause acne and inflammation. Phytosterol has a structure similar to cholesterol, so it can be used in skincare cosmetics to replace cholesterol. Phytosterol also has a similar effect to cholesterol on skin, which can increase skin elasticity and resist wrinkles, and help restore harmed skin. Compared with cholesterol, phytosterol is featured with the functions of anti-oxidation, anti-inflammation, anti-irritation, etc. Recently, German studies have further discovered that (Hautarzt. 2008 Jul; 59(7): 557-62.) phytosterol can effectively inhibit the expression of the collagen-degraded matrix metalloproteins (MMPs), block the decreased synthetic expression of collagen COL1A1 and COL1A2 induced by UV irritation, and even promote collagen expression. Therefore, it has a good moisturizing and anti-wrinkle effect and is an ideal anti-aging active substance. With high permeability to skin, phytosterol can maintain the moisture on the surface of your skin, promote skin metabolism, inhibit skin inflammation, prevent sunburn erythema, skin aging, facilitate hair growth, and nourish hair.

Phytosterol completely inhibits sunburn cell production (MED: minimum erythema dose, UV units)

Use:Add it at room temperature. You may heat it to above 40 °C to speed up its dissolution; recommended dosage: 1-5%. It works better with products such as nano vitamin A and ceramide.

Storage: Keep it away from light at a temperature below 25℃.

NanoActive Lutein is a new lutein nano liposome preparation (NanoLiposomal Lutein).
Product Name: Nano Liposomal Lutein; Nanoactive Lutein; BioaActive Lutein; Soluble Lutein CAS: 127-40-2

Description: Lutein, also known as plant lutein, coexists with zeaxanthin in nature. It is the main pigment that forms the macular area of the human eye. Human eyes contain high amounts of lutein which can only be supplemented by the intake of lutein as human body can not produce this element by itself. Without lutein, human will lose eyesight. A natural carotenoid found in vegetables and fruits, Lutein is a good antioxidant that protects cells in human body from the damage of free radical. Lutein is good for vision health as it can resist sunlight, blue light in computer and cellphone screens, relieve eye fatigue, sore eyes, tears, myopia, and prevent eye diseases such as cataracts and maculopathy. The skin is the only barrier between internal and external environment for human body. Lutein also plays a role in filtering blue light and strong anti-oxidation for the skin, greatly avoiding the damage of light to skin cells and preventing various kinds of skin disease caused by intense light stimulation. The high-energy blue light from electronic screen inhibits the generation of melatonin, penetrates deep into the skin layer, damages collagen, hyaluronic acid and elastin, accelerating skin aging, and may cause bad skin conditions such as enlarged pores, dark circles and hemorrhoids. Functioning as blue light filter and anti-oxidation agent, Lutein is the most effective biological actives that protects the skin from high-energy blue light. NanoActive Lutein developed by new nano-transfer technology solves lutein’s problems including low solubility, low stability and tendency to lose or change color, which make it hard to apply in skin care products. It is a multi-effect skincare actives that is anti-blue light, anti-oxidation and anti-aging. Lutein also performs well in skincare products, eliminating ubiquitous blue light and free radicals.

• Effectively inhibits the formation of harmful free radicals, slows down skin aging, and facilitates bright and elastic skin;
• Absorbs large amounts of daylight, computer light, and office lighting to protect skin against damage caused by UVA/UVB and blue light.

A type of carotenoid, Lutein is a natural colorant or pigment. It is found in dark green leafy plants such as spinach, various fruits and corn. The egg yolk also contains lutein. Lutein nutritionally supports human eyes and skin. The eye is the only organ in our body that receives external light stimuli, while the skin is the only one that is directly exposed to the external environment. As an antioxidant, Lutein can eliminate free radicals in human body or reduce its damage. Excessive free radicals can cause various chronic diseases. Lutein can improve vision and also ensure the health of the eye by reducing the risk of macular degeneration. Lutein can increase the skin’s antioxidant capacity and help prevent free radical damage.

Lutein structure

Mobile phones and computers are now indispensable in urbanites’ lives. Smartphones and computers can cause the same damage to our skin as ultraviolet rays from the sun because the blue light emitted by the screen can inhibit melatonin generation and penetrate deep into the skin layer, damaging collagen, hyaluronic acid and elastin, and accelerating skin aging. It can also cause skin problems such as enlarged pores, dark circles, and hemorrhoids.

Lutein is the most effective active against blue light damage. It can filter out up to 90% of high-energy blue light from the visible spectrum. Blue light is different from the commonly known ultraviolet A and ultraviolet B in the invisible light spectrum. Blue light can trigger oxidation reactions and cause potential free radical damage for human organs such as eyes and the skin that are exposed to both indoor light as well as sunlight.

Lutein mechanism

The antioxidant activity of natural lutein can protect skin cells, by preventing oxidation and free radicals from the very beginning, and working effectively to whiten the skin, remove freckle and wrinkle, moisturize, increase skin elasticity, glossiness and smoothness, and delay skin aging.

As it is a fat-soluble compound, Lutein is hard to be absorbed by the skin with ordinary emulsions. The lutein nanoactive material with a particle size of less than 30 nm developed by the nano-transport system (NDS)completelysolves the solubility and stability problems of lutein, allowing lutein to be stably encapsulated in the nanocarrier so that it hugely improves absorption efficiencyandbio-availability and becomes suitable for aqueous agent system.

Product features ：

• NanoActive Lutein uses FDA GRAS grade materials for higher safety
• NanoActive Lutein is stable to heat, pH, and cuts, so it is convenient to use
• NanoActive Lutein greatly enhances the stability and bioavailability of lutein
• NanoActive Lutein improves the stability and absorption of other actives in the product
• NanoActive Lutein is 100% water soluble and has a wide range of applications

Product Effects:

• NanoActive Lutein protects the skin from blue light, increases the antioxidant effect of skin cells, and reduces the damage of free radicals to the skin;
• NanoActive Lutein is an active ingredient that works well to remove wrinkles, whiten the skin, anti-aging, moisturize and increase skin elasticity.

Product use: Add under low temperature; recommended dosage: 1-5%.

Product storage: keep away from light at a temperature below 25°C.

Nanoactive C is a novel vitamin C nanoliposome formulation (NanoLiposomal C).
Product Name: Nano Liposomal Vitamin C; Nanoactive Vitamin C; BioaActive Vitamin C; BioActive VC; NanoActive VC; Oil Soluble Vitamin C; Fat Oil Soluble Vitamin C; Water Soluble Vitamin C; CAS: 50-81-7

Description: Vitamin C (Ascorbic Acid), also known as L-ascorbic acid, is a water-soluble vitamin.” Vitamin C is an important antioxidant, involved in multiple reactions in vivo which has functions such as promoting collagen production, blocking melanin synthesis, scavenging free radicals, and preventing skin aging. It is one of the most classic and active actives in cosmetics. Vitamin C is insoluble in fat-soluble systems and extremely unstable in aqueous solution, which limits its use greatly. Although a variety of vitamin C derivatives have been developed and used, they must be converted into a prototype vitamin C into the body to function, and their activity is greatly reduced. L-Vitamin C (“Left C”) is the only form of vitamin C that can be directly absorbed by human skin. NanoActive C is a L-Vitamin C nano-active material developed by Nano Transmission System (NDS) and with an average particle size of less than 30 nm. It also solves the problem of solubility and stability of vitamin C, allowing vitamin C to be stably encapsulated in nano-carriers. It can greatly increase the absorption rate and bioavailability, and greatly expand its application range.

Vitamin C

Vitamin C physiological activity

• Ascorbic activity (promotes collagen synthesis)
• Resistance to oxidation
• Inhibition to melanin synthesis
• Improvement in immune system

Features

• NanoActive C is a non-chemically modified stable L-C nano product that works directly and efficiently without the need of vivo transformation.
• NanoActive C uses GRAS (Recognized Safety) grade materials for high safety and non-irritation
• NanoActive C is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.
• NanoActive C greatly improves the stability and bioavailability of vitamin C
• NanoActive C is stable to heat, pH and shearing, so it is convenient to use.

Distribution map of NanoActive C particle size

Efficacy:

• NanoActive C inhibits melanin formation and reduces melanin by inhibiting tyrosinase activity. It also diminishes formed spots, eliminates pigmentation, and reduces sunburn and freckles caused by sunlight.
• It protects the skin from lesions caused by UV rays, such as the skin lines acquired.
• L-Vitamin C is an essential ingredient in the manufacture of collagen, and collagen is the main component of the dermis. NanoActive C promotes collagen synthesis to reduce fine lines.
• NanoActive C can effectively neutralize free radicals, promote skin metabolism, accelerate skin rejuvenation, improve skin texture, restore damaged skin, and make skin firm and elastic
• NanoActive C can improve the stability of other active matters in the product and facilitate absorption

Melanocytes

Whitening mechanism of NanoActive C

Vitamin C inhibits UV-induced skin damage

Vitamin C inhibits melanin production in B16 melanocytes

Vitamin C promotes collagen synthesis in human fibroblasts

Potential use of NanoActive

1. Maintanance of skin elasticity

– Enhance collagen synthesis

2. Whitening effect

– Antioxidant (reduction)

– Inhibition to tyrosinase activity

3. Prevent skin inflammation and photoaging

– Antioxidant (eliminating hydroxyl radicals)

Use:add it at ordinary temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Better effect with products containing vitamin E and ferulic acid.

Storage: keep it away from light at a temperature below 25℃.