ナノ活性硫黄（Nanoactive Sulphur）は、新しい硫黄ナノリポソーム製剤（NanoLiposomal Sulphur）である。
Product Name：Nano Liposomal Sulfur;Nanoactive Sulfur;BioaActive Sulfur;Soluble Sulfur
CAS:7704-34-9
説明：
硫黄は、古くから使われている、様々な皮膚病の治療に有効な薬であり、地殻に広く分布している黄色の非金属元素でもある。硫黄の働きは肌との直接の相互作用によるものである。粒子が小さいほど、硫黄は皮膚との相互作用の有効面積が大きく、効果も高い。ナノ活性硫黄は、トラブルのある肌に対する抗菌、抗炎症および皮脂調節という三つの機能を持つ皮脂調節剤である。水溶性で肌に刺激を与えず、化粧品成分として皮脂腺の分泌を調節し、美白機能を促進し、抗菌作用を持ち、ニキビやふけにもよい効果がある。硫黄は、ダニ・細菌・真菌殺滅、油脂除去、表皮軟化や角質溶解の働きを持つ。その作用機序は硫黄が皮膚及び皮下組織分泌物と接触すると、硫化水素とペンタチオニン酸を生成する結果である。
ナノ伝送システム（ＮＤＳ）により開発された、30nm未満の粒径のリポ酸ナノ活性物質は、硫黄の溶解性問題を完全に解決し、硫黄をナノキャリアに安定に封入させ、吸収効率とバイオアベイラビリティを大幅に向上させることができる。
リポ酸の構造
Sulphur is a yellow colored non-metal element, widely distributed throughout the planet. Different sulphur-based topical preparations have been developed through the years.
Sublimed sulphur is prepared by changing sulphur from solid to gas (sublimation). The resulting gas is subsequently condensed into fine yellow powder, which can be used in different ways. The physical properties of sublimed sulphur differ from those of precipitated sulphur. Sublimed sulphur, washed sulphur, or flowers of sulphur, is made of large particles with mild therapeutic efficacy; it is yellow, non soluble in water or alcohol, slightly soluble in olive oil (10%) and tastes slightly acidic. Washed sulphur is sublimed sulphur, treated with diluted ammoniac first and boiling water afterwards. Precipitated sulphur, also called magistery of sulphur or milk of sulphur, is made of small particles with high therapeutic efficacy; it is whitish-yellow, non soluble in water, slightly soluble in alcohol, soluble in 1:100 olive oil and insipid.
Nanoactive sulphur consists of minute particles, smaller than those of precipitated sulphur (1 to 100 nm), which can be suspended in a colloidal solution. So far, this form is considered the most active one. Currently, the so-called biosulphur is most frequently used, because of its better diffusion and higher activity on the skin.
TRADITIONAL USES
Sulphur has been used for medicinal purposes since the times of Hippocrates. Commercially, this product is important to produce sulphuric acid, abundantly used in the chemical industry and others.
COSMETIC PROPERTIES
Keratolytic properties
The action of sulphur depends on its direct interaction with the skin. The smallest particle sizes have the largest interaction area and therefore, they are most efficient. For many years, sulphur has been considered a specific remedy for seborrhea, used as octahedral sulphur solution in disulphide carbon or as colloidal dispersion. The therapeutic effects of sulphur on acne-prone skin or skin with excessive sebum secretion could result from its keratolytic action. The mechanism underlying such effect is not known; it probably depends on the interaction of sulphur with the cysteine into keratinocytes
Cystine is a major constituent of the horny layer. This reaction promotes normal keratinization, due to the keratoplastic effect of sulphur, applied at low concentrations.Applied at high concentrations, the same reaction causes keratolytic effects, because sulphur hydrogen breaks keratin.It is possible that applications of high sulphur concentrations on the skin result in sulphur hydrogen accumulation enough to dissolve the horny layer
Therefore, nanoactive sulphur fluid is recommended to formulate cosmetic products with regulatory activity on sebum secretions.
Antifungal action
Sulphur antifungal action depends on the conversion of sulphur into pentathionic acid, a
compound toxic to fungi. Sulphur hydrogen formation could also be involved in this action.
Applied on the skin, sulphur turns into pentathionic acid due to the action of skin bacteria and
keratinocytes. Furthermore, the keratolytic action of sulphur could cause the fungi to detach from the horny layer
Therefore, nanoacive sulphur fluid is recommended to formulate cosmetic products with purifying and antiseptic action
COSMETIC APPLICATIONS
製品の特徴
- NanoActive Sulfurは、FDA GRASレベルの材料を使用し、安全性が高い
- NanoActive Sulfurは、熱・pH・せん断安定性に優れ、使いやすい
- NanoActive Sulfurは、ALAの安定性とバイオアベイラビリティを大幅に向上させる
- NanoActive Sulfurは、製品の中の他の活性物質の安定性を向上させ、吸収を促進することができる
- NanoActive Sulfurは、水溶性も油溶性も100％（両親媒性）、幅広い用途に使える
製品の使用：室温で入れ、40℃以上に加熱すると溶解を速めることができる。推奨用量：1-3%。リポ酸などの製品と併用してよりよい効果が得られる。
製品の保管：25℃以下の暗所で保管してください。